Bio Technology Engineering

Biotechnology is often used to refer to genetic engineering technology of the 21st century. However the term encompasses a wider range and history of procedures for modifying biological organisms according to the needs of humanity, going back to the initial modifications of native plants into improved food crops through artificial selection and hybridization.


“Department of Biotechnology strives to provide a platform for students in various frontiers of Biotechnology by inspiring the next generation to achieve academic and research excellence for the betterment of mankind and society.”


“The Biotechnology Department committed to produce quality Biotechnology engineers, providing excellent analytical and entrepreneurial skills to achieve proficiency in industry and research fields for the betterment of mankind and society.”

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Bioengineering is the science upon which all biotechnological applications are based. With the development of new approaches and modern techniques, traditional biotechnology industries are also acquiring new horizons enabling them to improve the quality of their products and increase the productivity of their systems. The Biotechnology department was incepted in 2002 with UG and PG courses. In these 13 years of academic services, the department has grown up steadily, and at present the department hosts four autonomous programmes, under the affiliation of Visvesvaraya Technological University, Belgaum. The courses are designed to give theoretical and practical skills essential for a career in Biotechnology within the companies and research organizations. The courses are delivered through lectures (from highly qualified and dedicated staff who are experienced in and outside the country, and from eminent scientists from various institutions), laboratory classes, demonstrations, project work and workshops.

Course modules are assessed by variety of different types of course work including written assignments, oral presentations, poster presentations and examinations. The research project involves design, implementation and reporting of a major research task. We are one of the largest Biotechnology departments in the world and carry out world-class research and teaching. Our researchers come from a range of disciplines and work in a collaborative environment on all aspects of modern biotechnology. As a part of the research work, faculty members of the department have contributed to more than 400 International journal publications, presented 355 papers at international and national level conferences in the last three years. The Biotechnology students have participated and presented papers and posters at the various national and international conferences and have received many mini project grants from KSCST, Govt. of Karnataka. In the course of time, the Department of Biotechnology has become one of the best learning centers of Biotechnology in the country.

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Under Graduate

B.E. in Bio Technology Engineering
Duration: 4 Years

Eligibility : Pass in 10+2 / Higher Secondary (HS) / Pre University (PUC) / 'A' Level (with 12 years of schooling) or its equivalent with English as one of the languages. Shall have secured a minimum of 45% marks in aggregate in Physics, Mathematics and any one of the following : Chemistry, Biology, Biotechnology, Computer Science, Electronics, Information Science. AIT admits students as per prevailing rules and regulations of VTU.

Post Graduate

M.Tech in Bio Technology
Duration: 2 Years
Eligibility: BE / Equivalent Degree

Career Scope Successful students can aspire rewarding careers as Scientists in R & D laboratories and also as Process Engineers and Quality Control Managers in chemical and biotech industries.

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Chief Advisor

Dr. Sharanabasava C Pilli

Acharya Institute of Technology.


Dr. S M Gopinath

Head, Department of Bio Technology Engineering.

Member Secretary

Dr. M Ismail Shareef

Associate Professor,
Department of Bio Technology Engineering.


Dr. Arun S Ninawe

Advisor (Scientist G),
Department of Biotechnology, CGO Complex, New Delhi.

Dr. Dipankar Chatterjee

Honorary Professor, Molecular Biophysics Unit,
Indian Institute of Science, Bengaluru.

Dr. Dinesh Rangappa

Professor & Chairman, Dept. of Nanotechnology,
Center for P G Studies VTU, Bengaluru Region.

Mr. S S Easwaran

Academic Director, Biocon Academy.

Mr. Milind Sagar

Associate Scientist, In-vivo Biology,
Syngene International Ltd.


Dr. Lingappa

Professor, Department of Microbiology,
Gulbarga University, Gulbarga.

Mr. Srivatsa Rao

Assistant General Manager,
Regulatory-SCI Biocon Research Limited.

Dr. Garima Mishra

Associate Scientific Manager,
RND Biocon Research Limited.

Dr. Rafiq Ahmed

Principal, Research Scientist Discovery Science Group,
The Himalaya Drug Company.

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Nanotechnology, an interdisciplinary research field involving chemistry, engineering, biology, and medicine, has great potential for early detection, accurate diagnosis, and personalized treatment of cancer. Nanoparticles are typically smaller than several hundred nanometres in size, comparable to large biological molecules such as enzymes, receptors, and antibodies. With the size of about one hundred to ten thousand times smaller than human cells, these nanoparticles can offer unprecedented interactions with biomolecules both on the surface of and inside the cells, which has revolutionized cancer diagnosis and treatment. Many metal oxide nanoparticles have been investigated for biomedical applications targeting cancer. Metal oxide nanoparticles can be engineered as nanoplatforms for effective and targeted delivery of drugs and imaging labels by overcoming the many biological, biophysical, and biomedical barriers. However, several barriers exist for in vivo applications in preclinical and potentially clinical use of nanotechnology, among which are the biocompatibility, in vivo kinetics, tumour targeting efficacy, acute and chronic toxicity, ability to escape the reticuloendothelial system and cost-effectiveness. The ultimate goal is that low cost nanoparticle-based agents can allow for efficient, specific in vivo delivery of drugs without systemic toxicity, and the dose delivered as well as the therapeutic efficacy can be accurately measured noninvasively over time. Many factors need to be optimized simultaneously for the best clinical outcome.
Pharmacology is the study of the biological effects that the chemicals in medicinal plants have on cell cultures, animals and humans. Pharmacognosy is the study of drugs of natural origin "the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources". Plant preparations are said to be medicinal or herbal when they are used to promote health beyond basic nutrition. The study of drugs from plants includes the subjects of botany, chemistry and pharmacology. Chemical characterization of includes the isolation, identification and quantification of constituents in plant materials.
It dispense recent study and innovation of significant methods and techniques involved in molecular biology and relevant areas. The research scope embraces information on DNA, RNA and protein interactions, regulation of molecular pathways and manipulation of genetic material of an organism using scientific and technical advances.
A new, multi-disciplinary research field pertaining to action of chemicals, drugs, or natural products to animals or humans. The research field covers mechanistic approaches to physiological, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses.
The Dairy Science and Food Technology provides scientific and technological information, Cloud-based tools on starter cultures, probiotics, cheese science and technology, bioactive peptides, ice cream, wine making, modelling in food technology, thermal processing and modified atmosphere packaging and labelling. Some general health information including reference to allergy and food intolerance is also presented.
Environmental biotechnology is field a multidisciplinary integration of sciences and engineering in order to utilize the huge biochemical potential of microorganisms, plants and parts thereof for the restoration and preservation of the environment and for the sustainable use of resources.
The novel and exciting findings in research of plant biotechnology can be potentially applied in agriculture, horticulture, food and food-processing, paper, pulp and timber, pharmaceuticals, medical, phytoremediation, marine applications, non-food uses of plants and industrial crops. With the rapid developments in genomic sequencing and analysis, and availability of new technologies to analyse functional genomics and proteomics, the combined powers of genetics, biochemistry and cell biology are leading to the very rapid production of new information. Plant Biotechnology research field welcomes the results of these programmes when the outcome is likely to enhance the application of plant science to the above industries.
The field of structure-based drug design is a rapidly growing area in which many successes have occurred in recent years. The explosion of genomic, proteomic, and structural information has provided hundreds of new targets and opportunities for future drug lead discovery. One of the most pressing issues facing the pharmaceutical industry is the tremendous dropout rate of lead drug candidates. Genomics and proteomics are today well established in drug discovery and development, in combination with combinatorial chemistry and high-throughput screening, are helping to bring forward a matchless number of potential compounds. Over the last two decades, several new genomic technologies have been developed in hopes of addressing the issues of target identification and authentication of biomaterial.
Experiments on biological processes typically produce long sequences of successive observations on each experimental unit (plant, animal, bioreactor, fermenter, or flask) in response to several treatments (combination of factors). Cell culture and other biotech-related experiments used to be performed by repeated-measures method of experimental design coupled with different levels of several process factors to investigate dynamic biological process. Developing a bioprocess model can not only reduce cost and time in process development, but now also assist the routine manufacturing and guarantee the quality of the final products through Quality by Design (QbD) and Process Analytical Technology (PAT). However, these activities require a model based process design to efficiently direct, identify and execute optimal experiments for the best bioprocess understanding and optimisation. Thus an integrated model based process design methodology is desirable to significantly accelerate bioprocess development. This will help meet current urgent clinical demands and also lower the cost and time required. This thesis examines the feasibility of a model based process design for bioprocess optimisation. A new process design approach has been proposed to achieve such optimal design solutions quickly, and provide an accurate process model to speed up process understanding.
Bioprocess control and optimization is important in order to accomplish the broad objectives of maintaining a desired environment for growth of microorganisms. . In fact, in many aspects the monitoring and control situation is necessary to reach an economically feasible production with acceptable product quality. An optimized process leads to streamlined performance, reduction in running and material costs and improvements in quality control. The effective monitoring of bioprocess is necessary to develop, optimize and maintain biological reactors at maximum efficiency. Furthermore, due to the nature, type and volume of products produced in bioprocesses, there is a strong economic incentive for process monitoring for increasing yield and productivity. Biotechnological processes are dynamic and involve continuous changes to the physicochemical conditions of the medium. This in turn influences the functioning of the biocatalyst. The response to changes in the process environment is less reproducible making the tasks of process development, optimization and scale up difficult. Furthermore, bioprocesses inherently are batch oriented. Individual process steps need to be optimized and improved upon to adapt to the progress in process technology. This needs factual insight of the process state and understanding of the biochemical and metabolic control mechanisms. Production of recombinant protein is a fast growing area and the requirements of bioprocess monitoring and control in such processes is crucial for selecting optimal expression conditions. These emphasize the requirement of better tools and systems for online monitoring and control with insight into biochemical variables in the bioprocess. Automation and process monitoring ensures adherence to standards and regulations and generates much related process documentation [2, 3]. The need for quality monitoring is higher for biotechnological applications which involve intense downstream processing steps. Furthermore, it is significant from the point of view of environmental control and food safety. This ensures better process engineering, stringent quality and optimized processes. In addition, integration of individual processes is vital right from the field devices sensing the physical and biochemical parameters to higher layer controllers, supervisory and expert systems and application software. In fact, integrated control promotes optimization of bioprocesses and informed decision making in real time by employing Manufacturing Execution Systems (MES) [4]. Certainly, with the process analytical technology initiative (PAT) of FDA, this has gained more momentum.
The Biochemical Engineering research aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology. Biochemical engineers translate exciting discoveries in life sciences into practical materials and processes contributing to human health and well-being.

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The educational objectives of a program are the statements that describe the expected achievements of graduates within first few years of their graduation from the program. The program educational objectives of Bachelor of Engineering in Biotechnology can be broadly defined on four counts.

1. Knowledge and Skill

Graduates in Biotechnology work collaboratively, creatively, and communicate effectively in applying discipline-specific knowledge in basic sciences, chemical engineering and biotechnology.

2. Innovation

Graduates in Biotechnology students serving in entrepreneurial ventures and fostering activities that support sustainable economic development that enhance the quality of life of people in the state, across the country and around the globe.

3. Professionalism

Graduates in Biotechnology recognize the need for excellence and proficiency required for high quality industrial, academic and other professional areas.

4. Contribution

Graduates in Biotechnology exhibit broadened perspective regarding social issues, responsibilities, ethics and professionalism.

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Program outcomes are narrower statements that describe what students are expected to know and be able to do by the time of graduation. These relate to the skills, knowledge and behavior.

a. Engineering Knowledge

An ability to apply knowledge of mathematics, science, and engineering for solving Biotechnology problems.

b. Problem Analysis

An ability to identify, formulate, and solve technological problems relevant to bioscience.

c. Design/Development of Solutions

An ability to identify needs of the society with reference to public health, environmental issues and design technology driven solutions.

d. Conduct Investigations of Complex Problems

The broad education necessary to understand the impact of engineering solutions in a global, economic, environmental and societal context.

e. Modern Tool Usage

An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice.

f. The Engineer and Society

An ability to conduct real time experiment and process to meet the desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability and sustainability.

g. Environment and Sustainability

Create facility to protect the environment and encourage research in the various fields for making it a safe place to live in.

h. Ethics

An understanding of professional and ethical responsibility.

i. Individual and Team Work

An ability to function on multidisciplinary teams.

j. Communication

An ability to communicate effectively to understand research literature, identify thrust areas and evolve methods of analysis for solving multidisciplinary challenges.

k. Project Management and Finance

Competency for establishing Biotechnology based industry.

l. Life-Long Learning

A recognition of the need for and an ability to engage in life-long learning in new trends of Biotechnology from time to time.